When it comes to treating hyperpigmentation , dark spots , and melasma , Tri-Luma is often considered a gold-standard treatment. However, with the introduction of Tri-Luma RD , many users wonder which version works better and what the key differences are between the two. In this article, we will compare Tri-Luma RD with the regular Tri-Luma cream to help you decide which one is best suited for your skin care needs. What is Tri-Luma Cream? Tri-Luma is a prescription-strength topical treatment designed to treat melasma and other forms of hyperpigmentation. The cream combines three active ingredients that work together to lighten the skin , reduce inflammation , and promote cell turnover . These ingredients include: Hydroquinone – A potent skin-lightening agent that reduces melanin production , helping to fade dark spots and uneven skin tone. Tretinoin – A form of Vitamin A that promotes skin cell turnover , sloughing off pigmented skin and revealing fresh, even-toned s...